Sydney Brenner, a Nobel Prize winner whose study of the Round of Worms, which Caenorhabditis elegans led to discoveries in genetics and developmental biology, died today in Singapore. He was 92 years old
Brenner identified the main steps in how cells use DNA to create proteins that allow life. He found that sequences from the three bases of DNA denote the amino acids that form proteins. And he discovered that the RNA molecules carry this information to the ribosome cellular machines that produce these molecules.
Brenner pioneered another major breakthrough in biology: the discovery and development of a transparent worm that C. elegans as an ideal animal model; worms & # 39; is used today in laboratories around the world. His early studies in C. elegans and research in subsequent years led to the acquisition of the Nobel Prize in Physiology or Medicine in 2002 with two colleagues, John Swultson and H. Robert Horvitz. The Nobel Committee wrote that the study of the worm helped to identify "key genes that regulate the development of organs and programmed cell death … and [it] shed light on the pathogenesis of many diseases."
Brenner was born in a Jewish parent's parents in South Africa, where his father worked as a shoemaker, and he discovered an early speed for science by entering a Johnsburg medical school at the age of 15. Brenner quickly traveled to genetic research: he met with Francis Crick's DNA co-author in 1953 and soon moved to university. Cambridge in the UK to work with him. As The Guardian said in an obituary, Brenner and Creek "shared their office for 20 years, speaking continuously, laughing and doing hundreds of ideas they tested in the lab with their indispensable researcher Leslie Barnett."
Brenner, who was also known as an adept-practical joke, continued to work in his 90's and was married to almost 60, his wife, May, died in 2010. His three children and stepchildes survived.