British scientists have identified six different “types” of COVID-19 with specific clusters of symptoms – which can help treat a deadly infection.
The study, conducted by King’s College London, analyzed data from approximately 1,600 coronavirus patients in the UK and US who regularly recorded their symptoms in a follow-up supplement in March and April.
The results showed that by the fifth day of the virus’s progression, six different groups of symptoms appeared, which the researchers thought could help doctors better treat individual patients by predicting what level of hospital care they needed.
“Our study illustrates the importance of monitoring symptoms over time to make our predictions of individual risk and outcomes more accurate and accurate,”; said lead researcher Dr. Carol Sudre of London College College.
“This approach helps us understand each patient’s detailed history of the disease so that they can receive the best care.”
All people who reported their symptoms experienced olfactory loss and headache, but then had a different combination of lesser-known side effects, such as established disease – including confusion, abdominal pain, and shortness of breath.
The six clusters were broken down by severity as follows:
- Influenza without fever: Headache, odor loss, muscle aches, cough, sore throat, chest pain, no fever.
- Flu-like with fever: Headache, loss of smell, cough, sore throat, hoarseness, fever, loss of appetite.
- Gastrointestinal tract: Headache, odor loss, loss of appetite, diarrhea, sore throat, chest pain, no cough.
- Severe first, fatigue: Headache, odor loss, cough, fever, hoarseness, chest pain, fatigue.
- Severe second, confusion: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain.
- Severe level 3, abdominal and respiratory: Headache, odor loss, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, shortness of breath, drift, diarrhea, abdominal pain.
The first three clusters were more common in younger and healthy patients, while the last three more “severe” symptoms were more likely in elderly patients or in those with pre-existing conditions such as diabetes, lung disease and obesity.
Only 1.5% of people with cluster 1, 4.4% of people with cluster 2, and 3.3% of people with cluster 3 needed respiratory support, such as extra oxygen or ventilators, the researchers found.
But the probability of the need to maintain respiration has increased in the last three clusters – 8.6%, 9.9% and 19.8%, respectively.
Nearly half of cluster 6 patients were hospitalized, compared with only 16% of group 1 patients. Most patients with COVID-19 who need to breathe are hospitalized about day 13 after the first symptoms, the researchers said.
But being able to identify which cluster a patient falls into by the fifth day of symptoms will give doctors an early warning as to whether a person will need intensive care.
“These findings are important for the care and observation of people who are most vulnerable to severe COVID-19,” said Dr. Claire Steves of King’s College London.
“If you can predict who these people are on the fifth day, you have time to provide them with support and early intervention, such as monitoring their oxygen and blood sugar levels and ensuring they are properly hydrated – simple care that can be provided at home. preventing hospitalization and saving lives. “
The first group accounted for the largest share of participants, with 462 patients, while the second group had 315 patients, the third – 216, the third – 280, the fifth – 213, the sixth – 167.
The study was not reviewed.