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By Jaclyn Jeffrey-Wilensky
Counterfeit blood vessels begin to get real. New studies have shown that bioengineerous blood vessels are capable of incorporating living cells after implantation into the human body, becoming bloody, self-sustaining tubes that function less as substitutes for human blood vessels and more like real things. 1
"This is the wave of the future," said Lola Eniola Adefeso, a University of Michigan professor of biomedical engineering who was not involved in the study described on March 27 in Science Translational Medicine.
For researchers, scientists and biomedical engineers at Yale University and Humacyte, Regenerative Medical Technology in Durham, North Carolina has created HAVs, taking arterial cells from corpses, growing them in new blood vessels, and then removing cells. After treatment, all that was left was the so-called cell matrix – the web of collagen and protein, which gives the vessel its structure.
Then BAV were implanted in the hands of 60 patients with kidney disease in Durham; Norfolk, Virginia; and three cities in Poland. HAVs were used during hemodialysis sessions three times a week, which cleanses the blood that receives diseased kidneys. Hemodialysis, as a rule, is injected through the fistula, a surgical link between the artery and the vein that is easy to obtain; or through a graft that connects two blood vessels through a synthetic tube. Both approaches have disadvantages: Not all patients are good candidates for fistulas, and transplants are prone to clots and infections
Researchers watched patients for three years after they received their implants. Whenever a participant participated in planned surgery to correct or maintain his implant, the researchers collected a tiny area of their artificial vessels. All researchers received samples from 13 patients. Further analysis of the samples showed that the pre-built matrix was filled with its own cells of patients.
The analysis also showed evidence that artificial blood vessels were able to cure themselves. In one specimen, extracted 10 months after implantation, new cells were observed around the apertures exposed to the needles during dialysis.
Scientists from Yale University and Humacyte are also looking forward. Lawson said that artificial blood vessels could ever be on hand in hospitals.
"This science fiction concept of tissue engineering – we are on the verge of genuine," he said. more stories about bioengineering?
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