A brand new type of drug acting as a "Trojan horse" to get inside tumor cells has promising promise in patients with advanced, cancer-resistant drugs.
Patients with six different types of cancer, including cervical, bladder, ovarian, and lung tumors responded favorably to new treatments
Because these patients had already exhausted other treatments, the drug could be ready to prolong life beyond years old.
A new drug called tisotumab vedotin (or a TV for short) releases a toxic substance to kill cancer cells from the inside. The results were so positive that the drug is now undergoing Phase II testing for cervical cancer and will be tested in a series of additional cancerous tumors.
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The team of the Cancer Research Institute, London, and The Royal Marsden NHS Foundation Trust conducted the phase I / II global clinical trial nearly 1
The study was published in Oncology Lancet and funded by Genmab and Seattle Genetics.
Researchers have seen responses in 27% of patients with bladder cancer, 26.5% with cervical cancer, 14% with ovarian cancer, 13% with esophagus, 13% with non-small cell lung and 7% with endometrial cancer (although not in all men with prostate cancer).
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Responses lasted an average of 5.7 months, and in some patients – up to 9.5 months. The main side effects reported in the study were nose bleeding, fatigue, nausea and eye problems – but halfway through the study, researchers corrected the protocol to reduce these eye-related effects. tail end of the antibody. The antibody is designed to look for a receptor called "tissue factor" – present at high levels on the surface of many cancer cells and is associated with worse survival rates. Knitting with a tissue factor draws the drug into the cancer cells, where it can destroy them from the inside.
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Most of the patients in the early stages had a common stage cancer (locally or around the body) that had already been treated and Became resistant to three different types of treatment.
lies in the fact that his mechanism of action is completely new – he acts as a Trojan horse to penetrate cancer cells and kill them from within, "said Professor Johann de Bono of the Cancer Research Institute, London. 2] "Our early study shows that it has the potential to treat a large number of different types of cancer, and especially some of those with very low survival rates.
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"The TV has adverse side effects, and we have seen some good responses in patients in our test , all of which had cancer at a later stage, which was pre-treated with other drugs and other options.
"We have already begun additional trials of this new drug in various types of tumors and as the second line of treatment for cervical cancer, where the response rates were particularly high. We are also developing a test to select the patients that are most likely to respond.
The TV is now being tested in other types of cancer, including intestines, pancreatic, squamous lungs and head and neck, as well as in phase II
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The biopsy samples taken at the beginning of the study are currently being analyzed for expression of the tissue factor on tumor cells to see if it can be used as a marker to select the patients most likely to respond to preparation. , said: "We have seen significant successes against cancer in recent decades, but many types of tumors remain very difficult to treat as soon as the cancer has spread. We desperately need innovative treatments such as those that can attack cancer in new ways, and remain effective even against tumors that have become resistant to standard therapy.
for the treatment of cancer. I look forward to seeing his progress in the clinic and I hope that this can benefit patients who are currently undergoing treatment options. I
(Source: Cancer Research Institute, London)
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