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New drug boosts hope for the return of the loss of memory in old age Science



An experimental drug that supplements diseased brain cells increases the hope of cure for loss of memory, rejection of decisions and other mental disorders that often affect the elderly.

. 55 years of age, if clinical trials, which are expected to begin within two years, indicate that the drugs are safe and effective to prevent memory failure. . After two months of treatment, the researchers found that the brain cells that were reduced in animals grew back

Etienne Sibile, at the Center for Drug Addiction and Mental Health in Toronto, said that treatment was directed not only to "normal" . "A cognitive decline that leads to elevated moments, but with the loss of memory and mental disorders that usually affect people with depression, schizophrenia, and Alzheimer's. the age of 55-60, who may later be at risk for cognitive problems, may benefit from such treatment. " , decision making and meaningful life planning. "But we see this deficit because of the disorder from depression to schizophrenia and Alzheimer's."

There are no drugs on the market that would improve the loss of memory in old age and mental disorders such as depression and schizophrenia. Toronto researchers, however, believe that their medication can overcome the failures of memories, focusing on specific cells involved in learning and memories, and rejuvenating them. Changes that cause the brain in the body indicate that they can prevent memory loss at the onset of Alzheimer's and potentially delay its onset. His usual job is to slow down the speed with which the neurons of fire, effectively moisturizing the electric "noise" in the brain. To reduce this background noise and important signals in the brain can be more easily processed, or so the theory goes.

The new drug is a derivative of benzodiazepine, a family of medicines that includes anti-defective tablets Valium and Xanax. Although Valium and Xanax have broad brain effects, the new drug is designed to target specific "GABA receptors" found on neurons in key parts of the brain such as hippocampus, which are actively involved in cognition. The drug on mice in the labyrinth and found that half an hour after receiving a single dose, the old animals performed almost the same as young mice. The drug also restored the work of young mice, whose memories were temporarily exerted by stress, kept in a closed space.

"An old mouse will naturally work on this test for about 50-60%. His work memory is mostly not working. But within 30 minutes after taking the drug, their performance returns to 80-90%, so it is almost at the level of the young mouse. We have a quick turnaround in the workforce shortage associated with the age, and it's exciting, "Sibiee said in an interview with the Guardian. Inject drugs into drinking water. "We can grow brain cells," said Sibil.

"They tend to decrease with age and they decrease with neurodegenerative diseases. We see that the cells grow to a level that is close to that of young animals. "

Laboratory tests did not show any benefit when the drug was given to healthy young animals, assuming that it would not work as a cognitive enhancer. and give people with superhuman skills skills to healthy people. "It's not a drug that a student would take if they wanted to be smarter when they were examining," said Sibil. Researchers filed for a drug on Wednesday before the annual meeting in the American Association for the Advancement of Science in Washington.

Scientists are now hoping to test the drug in humans. with depression When people are in a state of remission from depression, people with inadequate memory and other psychiatric disorders often have the most likely recurrence, said Sibil.

"If we could somehow cure these deficits, we could potentially have a serious impact on the trajectory of life for these people. It will be a player to play in how we treat depression.


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