SALT LAKE CITY – Researchers at the University of Utah have found that music could relieve pain and inflammation, and enhance the effects of pain relievers like ibuprofen and CBD.
Drs. Cameron Metcalf and Greg Bulaj have spent the past few years playing Mozart's music on the mice in a lab to try to unravel the secrets of epilepsy treatment and management of chronic pain. Pain and epilepsy, while they are different conditions, present similar struggles – limited treatment options, debilitating lack of control, and medications that just are not effective enough. Metacalf and Bulaj believe music (like Mozart) may be the answer.
"Cameron and I have been working on developing new drugs for pain and epilepsy," said Bulaj, a associate professor of medicinal chemistry at the University of Utah and Senior author on the paper. "I've also been looking at how drugs can work together with music."
Mozart has been shown in a variety of studies to mitigate the negative effects of epilepsy. Bulaj and his team hoped they might not only learn more about music's effect on the disorder but also have chronic pain symptoms.
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Bulaj and his team utilized the mice and rats in the study, controlling the conditions, so they all experienced the same living environment. . The same Mozart compositions have been shown to help epilepsy in the past to be used in the study, with jarring portions of songs smoothed out with minor editing to avoid stunning the animals.
The mice were exposed to music three weeks before their participation. in the treatment. According to the study, the control group and the study group were moved to a different room during the "dark cycle" and into a housing facility during the "light cycle". During the "dark cycle," the study mice were exposed to the music while the control group was exposed only to ambient noise.
All the pills were given one of four pain reliefs, including ibuprofen, levetiracetam, cannabidiol (CBD) and galanin analog NAX 5055, the study said. Specific injuries were inflicted on the mice to simulate post-surgical pain, and in some cases, a virus was induced to cause the mice to have episodes mimicking episodes.
The results showed that pain relief from ibuprofen-music pairs improved the results by more than 90 percent. The other models showed that inflammation was reduced by 70 percent.
"We were looking at inflammatory pain," explained Metcalf, a research associate professor in Pharmacology and Toxicology and the first author on the paper. "We asked first," Does it reduce inflammation? "Then we looked at whether it's reduced swelling alone and in combination with other established and experimental pain drugs. According to Metcalf, the results showed that the musical therapy itself had a bit of effect. When given in combination with various drugs, however, the positive effects on pain and inflammation treatment are very clear. "We have chosen a dose of ibuprofen, which has a relatively minimal effect," Metcalf said. "In animals that were previously exposed to music, we saw a great increase."
The results showed not only a marked decrease in epileptic test subjects, but also reduced the number of deaths associated with the condition.
"We used a model of epilepsy, and we did have an anti-seizure effect," explained Metcalf. "But what was most remarkable was that we actually saw a reduced mortality rate. The particular seizure model we're working with "
The researchers hope to further explore whether they can reduce epilepsy's mortality rate, in addition to controlling the number of lumps. could help in preventing Sudden Unexpected Death in Epilepsy
The researchers have already applied to continue their studies in a clinical setting on human subjects.
"One way we want to go forward is to understand what is it about This music and its components that give this kind of pain relief and drug enhancing effects, "Metcalf explained.
Bulaj was able to recruit collaborators from a local musical nonprofit, the Gifted Music School, who are working to analyze the compositions for better understand how the structure works.
"They have already identified things like rhythm, tempo, punctuation, phrases and sequences," Bulaj said. "We hope to look for this Mozart-like structure in other classical composers. Maybe (medical compositions) will even include Lady Gaga or Katy Perry. "
The study has potential limitations, with the largest among them being mice hearing at different frequencies than humans. The researchers believe that human trials will help answer the enigmatic questions arising from animal trials.