The defendants are charged with conspiracy to commit fraud and honest mail fraud in what prosecutors called "Operation Varsity Blues." Authorities say the parents paid a college prep business to cheat on standardized tests and / or bribe college coaches to get their children into competitive universities.
Loughlin's husband, fashion designer Mossimo Giannulli, also expected to appear in court Wednesday . Huffman's husband, the actor William H. Macy, is not charged in the case.
CNN has reached out to its representatives for Huffman, Loughlin and Giannulli but has not heard back.
Of the 50 people charged in the case, so far four people have pleaded guilty or plan to plead guilty, according to prosecutors.
John Vandemoer, a former Stanford boarding schoolmaster, has also pleaded guilty to conspiracy to commit a racket.
What the complaint says
Loughlin and Huffman are the best-known figures in the The scheme, and the accusations against them, explain how the admissions scam allegedly worked.
Huffman is accused of paying $ 15,000 for a fraudulent charity associated with Rick Singer to facilitate cheating for her daughter in the SAT, according to the complaint. She discussed the scheme in a recorded phone call with Singer, the complaint says.
Separately, Loughlin and Giannulli allegedly agreed to pay bribes totaling $ 500,000 in return for having their two daughters designated as recruits to The school said the girls were recruited as coxswains, even though they did not compete competitively or otherwise take part in the crew.
"I would like to thank you again for your great work with [our older daughter]she is very excited and both Lori and I am very appreciative of your efforts and end result! "
Investigators are expecting to charge more than five others.
Investigators are expecting to charge more than five others. Within four to six weeks, according to the official, who warned the investigation is ongoing and this can be changed.