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Cancer 'vaccine' shows promise in the human trial of lymphoma patients



They refer to it as a vaccine because it causes a person's immune system to fight the disease, although it's not a preventative like the flu shot. In this case, the treatment teaches the body to recognize tumors and attack them.

Researchers have created treatment directly within the tumor. To do this, they injected one tumor with a stimulant to recruit immune cells, treated the tumor with a low dose of radiation, then injected it with a stimulant to activate the immune cells.

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] In three of the patients, the treatment shrunk not only the tumor that was treated but also other ones throughout the body, putting these patients into remission.

"It's really promising, and the fact you get not only responses in treated areas , but areas outside the field [of treatment with radiation] is really significant, "said Dr. Silvia Formenti, chairwoman of radiation oncology at Weill Cornell Medicine and New York Presbyterian, who was not involved in the study and is working on a similar treatment.

While promising, the effect was observed only in three people and will need to be tested in larger trials before even going to the Food and Drug Administration for review.

Dr. Eric Jacobsen, a clinical director of the Dana-Farber Cancer Institute's lymphoma program, said the results are exciting but cautioned more research needs to be done. Jacobsen was not involved in the study.

"It's definitely proof of concept, but more studies are definitely needed and additional strategies to try to get more than three out of 1

1 patients to respond," said Jacobsen, who also develops Lymphoma vaccine, although with a slightly different approach.

Researchers for decades have tried, but failed to create cancer vaccines. New research on immunotherapy, or training a person's immune system to combat disease, has reinvigorated their efforts.

The vaccine activates dendritic cells that are responsible for initiating immune responses. Brody said.

The research was funded by The Damon Runyon Cancer Research Foundation, the Cancer Research Institute and Merck. Celldex and Oncovir provided the materials for the clinical trial and the lab work.

Correction: This article was revised to correct a quote from Dr. Forms She said "treated," not "three."

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