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A common household ingredient can sabotage antibiotics



Photo 2009 Toothbrush Toothpaste Colgate Total on it, a brand that once contained triclosan. The company changed its formula only this year.
Photo: Carolyn Custer (AP)

Your daily toothpaste or syringe for spraying your body may inadvertently spoil the treatment with antibiotics, offers new research. It was found that the common household antimicrobial ingredient – triclosen – reduces the potency of antibiotics used to treat urinary tract infections hundreds of times, at least in mice

. up to a lip gloss to a deodorant to household cleaners to rinse aid. Traditionally, it is advertised as an easy way to kill bacteria and mushrooms, it would seem, without harm to humans. In recent years, however, evidence of evidence suggests another.

In 2017, the Food and Drug Administration completed the prohibition of the use of triclosan and related chemicals in consumer soaps sold as antimicrobials. The agency provides evidence showing antimicrobial soaps with these ingredients that do not seem to prevent diseases or even kill bacteria better than a typical boiler of soap and hot water. Even more alarming is the growing body of evidence that shows that triclosan can really help in the creation of bacterial superbacteria. It is believed that the way triclosan stops bacteria is too similar to how many antibiotics perform this work. Thus, bacteria that develop resistance to triclosan will also learn how to protect these drugs. This is definitely a bad news, because the triclosan eventually ends everywhere in our environment, where it can promote broad resistance to antibiotics.

A new study published in Antimicrobial Agents and Chemotherapy is not a new basis for confirming this link. But the results indicate that triclosan has an effect on antibiotics and bacteria long before a chemical has entered the outside world – this can happen in our bodies.

Researchers first opened Petri dishes containing UTI-causing strains of Escherichia coli and methicillin-resistant Staphylococcus aureus (a superfruit also called MRSA) to doses of triclosan which is typically found in the consumer product. Then they tried to use conventional antibiotics that kill bacteria on them. Compared with non-exposed bacteria, Triclosan bacteria can carry antibiotics 1000 times better. The next team conducted a similar experiment with live mice, finding that bacteria that are exposed to triclosan could survive in mice up to 100 times better than control microbes.

"Usually, one in a million cells is experiencing antibiotics, and the immune system functions. can manage them. But the triclosan has changed the number of cells, "says lead author Peter Levin, a professor of biology at the University of Washington. "Instead of surviving only one million bacteria, one in 10 organisms survived in 20 hours. Now the immune system is full. "

Mice are not humans, so the study is limited to the fact that it can tell us about the resistance to antibiotics in humans. However, there is some reason to be worried. IMP, especially among women, is one of the most common infections that we rely on antibiotics for treatment. And even with the prohibition of antimicrobial soap, triclosan is still widespread. Other studies have shown that three quarters of Americans take enough triclosan to be found in urine.

Levin's work could also reveal one explanation why triclosan may stop the work of some antibiotics. Her team has found evidence that the chemical causes the production of a molecule called ppGpp, which slows down the growth of bacteria. These slower bacteria, which they theorize, can then better fight certain antibiotics. The mutant E. coli is not able to make PPGpp, created by the team, triclosan could not stop the work of antibiotics, adding more support to their theory. However, it is likely that ppGpp is just one of many ways of triclosan to affect antibiotic resistance.

In any case, at least some companies that introduce triclosan into their products are beginning to feel warm. Earlier this year, Colgate-Palmolive introduced a free version of Colgate Total toothpaste without triclosan. While still claiming that the original version, the only American brand toothpaste approved for the transfer of triclosan was completely safe and better for your dental health than competitors, the company now claims that its new version is made with tin fluoride , provides even more benefits.

If you are unsure whether you are currently using any products containing triclosan, the US Department of Health and Social Services has a handy list that you can check. [19659013]
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